Hearing Loss Due to Cyclosporine In Children
DOI:
https://doi.org/10.37762/jgmds.10-1.355Keywords:
Hearing loss, nephrotic syndrome, FSGS, cyclosporineAbstract
ABSTRACT
A 13-year-old boy known for steroid-resistant nephrotic syndrome taking cyclosporine for the last four years was referred from one private hospital for non-response to treatment and decreased hearing. On detailed history, it was revealed that hearing loss started after initiation of treatment with cyclosporine during the first year, and the patient was not properly followed for hearing issues. Rather cyclosporine was continued despite no response to treatment. The patient raised alanine transaminase (ALT) and uric acid levels. The drug was discontinued, and ALT and uric acid were normalized on follow-up. Hearing on follow-up improved clinically. It was concluded that children taking calcineurin inhibitors should be screened for hearing when taking them long.
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Liu Y, Yang R, Yang C, Dong S, Zhu Y, Zhao M, et al. Cyclophosphamide versus cyclosporine A therapy in steroid-resistant nephrotic syndrome: a retrospective study with a mean 5-year follow-up. Journal of International Medical Research 2018;46(11):4506–17
Prasad N, Manjunath R, Rangaswamy D, Jaiswal A, Agarwal V, Bhadauria D, et al. Efficacy and Safety of Cyclosporine versus Tacrolimus in Steroid and Cyclophosphamide Resistant Nephrotic Syndrome: A Prospective Study. Indian J Nephrol 2018;28(1):46–52
Liu C, Zhu P, Fujino M, Isaka Y, Ito H, Takahashi K, et al. 5-aminolaevulinic acid (ALA), enhances heme oxygenase (HO)-1 expression and attenuates tubulointerstitial fibrosis and renal apoptosis in chronic cyclosporine nephropathy. Biochem Biophys Res Commun 2019;508(2):583-9
Groenendyk J, Paskevicius T, Urra H, Viricel C, Wang K, Barakat K, et al. cyclosporine a binding to COX-2 reveals a novel signaling pathway that activates the IRE1alpha unfolded protein response sensor. Sci Rep 2018;8(1):16678
Liu Y, Yang R, Yang C, Dong S, Zhu Y, Zhao M, et al. Cyclophosphamide versus cyclosporine a therapy in steroid-resistant nephrotic syndrome: a retrospective study with a mean 5-year follow-up. J Int Med Res. 2018;46(11):4506–17
Li HY, Zhang X, Zhou T, Zhong Z, Zhong H. Efficacy and safety of cyclosporine a for patients with steroid-resistant nephrotic syndrome: a meta-analysis. BMC Nephrology 2019;20:384
Ahmed R, Hassan Z, Haseeb A, Masood A, Ali I. Multiple Adverse Drug Reactions to Calcineurin Inhibitors in a Renal Transplant Patient. Uro 2021;1:180–6
Hegemann SCA, Wenzel A. Diagnosis and treatment of vestibular neuritis/neuronitis or peripheral vestibulopathy (PVP)? Open Questions and Possible Answers. Otol Neurotol 2017;38:626–31. 10.1097/MAO.0000000000001396
Rizk HG, Lee JA, Liu YF, Endriukaitis L, Isaac JL, Bullington WM. Drug-Induced Ototoxicity: A Comprehensive Review and Reference Guide. Pharmacotherapy 2020;40(12):1265-75)
Rageh MTR, El-Nemr SB, El- Gharib AM, Abdelnabi HH. Effect of Cyclosporin A on Hearing Status in Children with Difficult to Treat Idiopathic Nephrotic Syndrome. Journal of Advances in Medicine and Medical Research 2021;33(1):17-28, 2021; Article no.JAMMR.64806
Franz L, Frosolini A, Parrino D, Lovato A, de Filippis C, Marioni G. Ototoxicity of Immunosuppressant Drugs: A Systematic Review. J Int Adv Otol 2022;18(2): 167-76
Waissbluth S. Is Cyclosporine Ototoxic? Front. Neurol. 11:593917
El-Farsy MS, Ibrahim MAA, Fatouh FN, Fattah ATA. Cyclosporine A effect on Hearing in Children with Steroid Dependent Nephrotic Syndrome and Steroid Resistant Nephrotic Syndrome. geget 2021;16(1):14-24
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Copyright (c) 2023 Syed Sajid Hussain Shah
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