Fetal Warfarin Syndrome – a case report
DOI:
https://doi.org/10.37762/jgmds.9-1.235Keywords:
Warfarin, Syndrome, Fetal Anomalies, TeratogenicAbstract
A two-month-old male infant presented with history of respiratory difficulty and got admitted with provisional diagnosis of pneumonia. On examination patient was having unilateral nasal hypoplasia and cyanosis with echocardiography showing truncus arteriosus. Detail history revealed that mother had valve replacement and she was taking warfarin during pregnancy. After initial management patient was referred to pediatric cardiac surgery and plastic surgery for further management. Parents were counseled regarding contraception and family planning.
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Sousa AR, Barreira R, Santos E. Low-dose warfarin maternal anticoagulation and fetal warfarin syndrome. BMJ Case Reports. 2018;2018:bcr-2017-223159 DOI: https://doi.org/10.1136/bcr-2017-223159
Güner A, Kalçık M, Gürsoy MO, Gündüz S, Astarcıoğlu MA, Bayam E, et al. Comparison of different anticoagulation regimens regarding maternal and fetal outcomes in pregnant patients with mechanical prosthetic heart valves (from the Multicenter ANATOLIA-PREG Registry). Am J Cardiol. 2020;127:113-9. https://doi.org/10.1016/j.amjcard.2020.04.010 DOI: https://doi.org/10.1016/j.amjcard.2020.04.010
Ali CA, Varghese TC, Sreenivasan VK. A preventable syndrome for a precious baby. Int J Orthop Sci. 2021;7(1):1022-3. https://doi.org/10.22271/ortho.2021.v7.i1o.2602 DOI: https://doi.org/10.22271/ortho.2021.v7.i1o.2602
Dhillon SK, Edwards J, Wilkie J, Bungard TJ. High-versus low-dose warfarin–related teratogenicity: a case report and systematic review. J Obstet Gynaecol Can. 2018;40(10):1348-57. https://doi.org/10.1016/j.jogc.2017.11.020 DOI: https://doi.org/10.1016/j.jogc.2017.11.020
Watkins DA, Johnson CO, Colquhoun SM, Karthikeyan G, Beaton A, Bukhman G, et al. Global, regional, and national burden of rheumatic heart disease, 1990-2015. N Engl J Med. 2017;(37):713-22 DOI: https://doi.org/10.1056/NEJMoa1603693
Remenyi B, El-Guindy A, Smith Jr SC, Yacoub M, David R Holmes Jr DR. Valvular aspects of rheumatic heart disease. Lancet. 2016;387(10025):1335-46. doi.org/10.1016/S0140-6736(16)00547-X DOI: https://doi.org/10.1016/S0140-6736(16)00547-X
Alrukban H, Chitayat D. Fetal chondrodysplasia punctata associated with maternal autoimmune diseases: a review. Appl Clin Genet. 2018;11:31-44 DOI: https://doi.org/10.2147/TACG.S150982
Songmen S, Panta OB, Paudel S, Ghimire RK. Chondrodysplasia punctata: a case report of fetal warfarin syndrome. J Nepal Health Res Counc. 2017;15(35):81-4 DOI: https://doi.org/10.3126/jnhrc.v15i1.18026
Panduranga P, El-Deeb M, Jha C. Mechanical prosthetic valves and pregnancy: a therapeutic dilemma of anticoagulation. Sultan Qaboos Univ Med J. 2014;14:e448-54
Singh A, Panghal A, Prasad R, Mishra OP. A case of coumarin embryopathy after in utero exposure to acenocoumarol. J Fetal Med. 2018;5:233-6. https://doi.org/10.1007/s40556-018-0182-2 DOI: https://doi.org/10.1007/s40556-018-0182-2
Conradie M, Henderson BD, van Wyk C. Preventable warfarin-induced birth defects: a missed opportunity?. S Afr Med J. 2019;109(6):415-20 DOI: https://doi.org/10.7196/SAMJ.2019.v109i6.13294
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Copyright (c) 2022 Syed Sajid Hussain Shah, Bibi Aaliya
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