Ivermectin Poisoning with Neurological Manifestations in 10 Years Old Girl – A Case Report

Syed Sajid Hussain  shah; Bibi  Aalia

doi:10.37762/jgmds.9-3.243

Authors

Syed Sajid Hussain shah IKD
Bibi Aalia

DOI:

https://doi.org/10.37762/jgmds.9-3.243

Keywords:

Ivermectin, Poisoning, Children, Seizures

Abstract

In developing countries, accidental poisoning is a serious public health problem in children. But unintentional poisoning by parents in the form of medication is very rare. Ivermectin belongs to the group of Avermectins and is used in veterinary medicine and in use for human parasitic diseases. We report the case of 10 years old girl given ivermectin by her mother for an unspecified amount. The patient presented to the hospital with seizures and remained in a coma for five days. The patient was managed symptomatically and discharged home in stable condition with parents' counselling regarding child safety.

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Author Biographies

Syed Sajid Hussain shah, IKD

Assistant Prof. Paediatric Nephrology,

Institute of Kidney Diseases, Peshawar

Bibi Aalia

MBBS , FCPS(Paediatrics)
Assistant Prof. Paediatrics, Lady Reading Hospital, Peshawar

References

Juarez M, Schcolnik-Cabrera A, Dueñas-Gonzalez A. The multitargeted drug ivermectin: from an antiparasitic agent to a repositioned cancer drug. American journal of cancer research. 2018;8(2):317

Bai SH, Ogbourne S. Eco-toxicological effects of the avermectin family with a focus on abamectin and ivermectin. Chemosphere. 2016 Jul 1;154:204-14 DOI: https://doi.org/10.1016/j.chemosphere.2016.03.113

Crump A. Ivermectin: enigmatic multifaceted 'wonder'drug continues to surprise and exceed expectations. The Journal of antibiotics. 2017 May;70(5):495-505 DOI: https://doi.org/10.1038/ja.2017.11

Foy BD, Alout H, Seaman JA, Rao S, Magalhaes T, Wade M, Parikh S, Soma DD, Sagna AB, Fournet F, Slater HC. Efficacy and risk of harms of repeat ivermectin mass drug administrations for control of malaria (RIMDAMAL): a cluster-randomized trial. The Lancet. 2019 Apr 13;393(10180):1517-26 DOI: https://doi.org/10.1016/S0140-6736(18)32321-3

Talwar N, Tripathi N, Chugh K. Ivermectin Poisoning—Report of Successful Management. Indian Pediatrics. 2021;58(9):893 DOI: https://doi.org/10.1007/s13312-021-2316-1

Juarez M, Schcolnik-Cabrera A, Dueñas-Gonzalez A. The multitargeted drug ivermectin: from an antiparasitic agent to a repositioned cancer drug. American journal of cancer research. 2018;8(2):317

Zhu M, Li Y, Zhou Z. Antibiotic ivermectin preferentially targets renal cancer through inducing mitochondrial dysfunction and oxidative damage. Biochemical and biophysical research communications. 2017 Oct 21;492(3):373-8 DOI: https://doi.org/10.1016/j.bbrc.2017.08.097

Galluzzi L, Buqué A, Kepp O, Zitvogel L, Kroemer G. Immunogenic cell death in cancer and infectious disease. Nature Reviews Immunology. 2017 Feb;17(2):97-111 DOI: https://doi.org/10.1038/nri.2016.107

Chosidow O, Bernigaud C, Guillemot D, Giraudeau B, Lespine A, Changeux JP, Bourhy H, Lecuit M, Amoura Z. Ivermectin as a potential treatment for COVID-19?. PLoS Neglected Tropical Diseases. 2021 Jun 1;15(6):e0009446 DOI: https://doi.org/10.1371/journal.pntd.0009446

Gwee A, Duffull S, Zhu X, Tong SY, Cranswick N, McWhinney B, Ungerer J, Francis J, Steer AC. Population pharmacokinetics of ivermectin for the treatment of scabies in Indigenous Australian children. PLoS neglected tropical diseases. 2020 Dec 7;14(12):e0008886 DOI: https://doi.org/10.1371/journal.pntd.0008886

Rubino F, Amiel SA, Zimmet P, Alberti G, Bornstein S, Eckel RH, Mingrone G, Boehm B, Cooper ME, Chai Z, Del Prato S. New-onset diabetes in Covid-19. New England Journal of Medicine. 2020 Aug 20;383(8):789-90 DOI: https://doi.org/10.1056/NEJMc2018688