The Relationship between Iron Deficiency Anemia and the Incidence of Febrile Convulsions

Authors

  • Mohsin Khan Author
  • Niama Khan Ayub Teaching Hospital, Abbottabad
  • Mudassir Abdul Jalil Mercy Teaching Hospital, Peshawar
  • Muhammad Asfandiyar Ali Ayub Teaching Hospital, Abbotabad
  • Jawad Khan Khan Ayub Teaching Hospital, Abbotabad
  • Mohsin Khan Ayub Teaching Hospital, Abbotabad

DOI:

https://doi.org/10.37762/jgmds.10-3.457

Keywords:

Febrile Convulsions, Seizures, Iron Deficiency Anemia

Abstract

OBJECTIVES

To determine the role of iron deficiency anemia in patients with febrile convulsions in the 06 to 60 months in a tertiary care hospital.
METHODOLOGY

This cross-sectional study was undertaken at Ayub Teaching Hospital, Abbottabad, from January 2020 to February 2022. Patients with typical and atypical febrile seizures were recruited for the study, while patients with neurodegenerative diseases, meningoencephalitis, epilepsy, trauma, nephritic syndrome, and hypertensive seizures were excluded from the study. Iron deficiency was identified concerning a complete blood count. The data were analyzed in SPSS version 21, and the significance value was kept at < 0.005.
RESULTS
In the present study, 102 patients were enrolled. The mean age of the sample was 15 months, with an age range of 6-54 months. The male-to-female ratio was 2:1. The mean haemoglobin (HB) of the sample observed was 9.9±1.9, mean corpuscular volume (MCV) 73±13, red cell distribution width (RDW) 16±7.9 white cell count (WBC) 12.9±7.1 and platelets of 312±180. The use of cow milk in febrile seizures was 41%, and only 33% of parents were unaware of proper milk dilution.

CONCLUSION

We concluded that patients with atypical febrile seizures and those with seizures more than once have a significantly higher degree of iron deficiency anemia than those with typical febrile seizures. Moreover, the group with prolonged seizures has severe anemia compared to the group with brief seizures.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Author Biographies

Niama Khan, Ayub Teaching Hospital, Abbottabad

Resident Gynecologist,
Ayub Teaching Hospital, Abbottabad

 

Mudassir Abdul Jalil, Mercy Teaching Hospital, Peshawar

Resident Pediatrician,
Mercy Teaching Hospital, Peshawar

 

Muhammad Asfandiyar Ali, Ayub Teaching Hospital, Abbotabad

Resident Physician,
Ayub Teaching Hospital, Abbotabad

 

Jawad Khan Khan, Ayub Teaching Hospital, Abbotabad

Resident Physician,
Ayub Teaching Hospital, Abbotabad

 

Mohsin Khan, Ayub Teaching Hospital, Abbotabad

Mohsin Khan, Resident Physician,
Ayub Teaching Hospital, Abbotabad

 

References

Fallah R, Tirandazi B, Ferdosian F, Fadavi N. Iron deficiency and iron deficiency anemia in children with first attack of seizure and on healthy control group: a comparative study. Iranian journal of child neurology. 2014;8(3):18

Mawani M, Ali SA, Bano G, Ali SA. Iron deficiency anemia among women of reproductive age, an important public health problem: situation analysis. Reproductive System & Sexual Disorders: Current Research.. 2016;5(3):1 DOI: https://doi.org/10.4172/2161-038X.1000187

Rudy M, Mayer-Proschel M. Iron deficiency affects seizure susceptibility in a time-and sex-specific manner. Asn Neuro. 2017 Dec;9(6):1759091417746521. DOI: https://doi.org/10.1177/1759091417746521

Ghosal S. Relationship of Iron Deficiency Anemia with Simple Febrile Seizure in Children. Journal of Bangladesh college of physicians and surgeons. 2017 Jul 29;35(2):75-9 DOI: https://doi.org/10.3329/jbcps.v35i2.33367

Laino D, Mencaroni E, Esposito S. Management of pediatric febrile seizures. International journal of environmental research and public health. 2018 Oct;15(10):2232 DOI: https://doi.org/10.3390/ijerph15102232

Papageorgiou V, Vargiami E, Kontopoulos E, Kardaras P, Economou M, Athanassiou-Mataxa M, Kirkham F, Zafeiriou DI. Association between iron deficiency and febrile seizures. European Journal of Paediatric Neurology. 2015 Sep 1;19(5):591-6. DOI: https://doi.org/10.1016/j.ejpn.2015.05.009

Heydarian F, Nakhaei AA, Majd HM, Bakhtiari E. Zinc deficiency and febrile seizure: a systematic review and meta-analysis. Turkish Journal of Pediatrics. 2020 May 1;62(3) DOI: https://doi.org/10.24953/turkjped.2020.03.001

World Health Organization. A Guide for Program Managers. Geneva: WHO/NHD/013; 2001. Iron deficiency anemia. Assessment, prevention and control

Bhat JA, Sheikh SA, Bhat SU, Ara R. Association of iron deficiency anemia with simple febrile seizures: a hospital-based observational case–control study. Menoufia Medical Journal. 2020 Jul 1;33(3):882.

Karimi P, Sayehmiri K, Azami M, Tardeh Z. The association between iron deficiency anemia and febrile seizure. International journal of adolescent medicine and health. 2022 Feb 1;34(1) DOI: https://doi.org/10.1515/ijamh-2019-0083

Ahmed BW, Hanoudi BM, Ibrahim BA. Risk factors in children with febrile seizures and their iron status. synthesis. 2019 Aug 1;1:2

Chaudhary BR, Karmacharya Malla K, Gaire B. Association of iron deficiency anemia with febrile seizure in children in a tertiary care hospital. J Nepal Health Res Counc. 2021 Apr 23;19(1):66-70 DOI: https://doi.org/10.33314/jnhrc.v19i1.3327

Vaswani RK, Dharaskar PG, Kulkarni S, Ghosh K. Iron deficiency as a risk factor for first febrile seizure. Indian pediatrics. 2010 May;47:437-9 DOI: https://doi.org/10.1007/s13312-010-0080-8

Malla T, Malla KK, Sathian B, Chettri P, Singh S, Ghimire A. Simple febrile convulsion and iron deficiency anemia a co-relation in Nepalese children. American Journal of Public Health Research. 2015 Oct 28;3(5A):p11-16

Daoud AS, Batieha A, Abu‐Ekteish F, Gharaibeh N, Ajlouni S, Hijazi S. Iron status: a possible risk factor for the first febrile seizure. Epilepsia. 2002 Jul;43(7):740-3. DOI: https://doi.org/10.1046/j.1528-1157.2002.32501.x

Billoo AG. Association between iron deficiency anemia and febrile seizures. Journal of the College of Physicians and Surgeons--pakistan: JCPSP. 2005 Jun 1;15(6):338-40

Bhat JA, Sheikh SA, Bhat SU, Ara R. Association of iron deficiency anemia with simple febrile seizures: a hospital-based observational case–control study. Menoufia Medical Journal. 2020 Jul 1;33(3):882

Aslan M. Evaluation of Patients Presenting With First Febrile Seizure. Cureus. 2021 Jul 3;13(7) DOI: https://doi.org/10.7759/cureus.16151

Downloads

Published

2023-07-01

How to Cite

Khan, M., Khan, N. ., Jalil, M. A. ., Ali, M. A. ., Khan, J. K., & Khan, M. . (2023). The Relationship between Iron Deficiency Anemia and the Incidence of Febrile Convulsions. Journal of Gandhara Medical and Dental Science, 10(3), 73–76. https://doi.org/10.37762/jgmds.10-3.457