Pleural Mesothelioma: Unexpected Finding in a Young Man
DOI:
https://doi.org/10.37762/jgmds.9-3.310Keywords:
Malignant mesothelioma, young patient, Pleural MesotheliomaAbstract
Pleural mesothelioma is the disease of the elderly, usually in the seventh decade of life. Asbestos exposure is the most common finding among these patients. Other causes include a simian virus, radiation exposure, genetic predisposition and erionite. Common symptoms include shortness of breath, weight loss, dull achy chest pain on the site of the lesion and anorexia. Pleural effusion is common and video-assisted thoracoscopic (VATS) biopsy is the investigation of choice. pleurectomy, pleuro-pneumonectomy and cisplatin-based therapy are management modalities depending upon the stage of the disease. We are presenting an unusual case of pleural mesothelioma in a young patient with no significant exposure to the causative agent.
Downloads
Metrics
References
Berzenji L, Van Schil P. Multimodality treatment of malignant pleural mesothelioma. F1000Res [Internet]. 2018;7:1681 DOI: https://doi.org/10.12688/f1000research.15796.1
Zha L, Kitamura Y, Kitamura T, Liu R, Shima M, Kurumatani N, et al. Population-based cohort study on health effects of asbestos exposure in Japan. Cancer Sci [Internet]. 2019;110(3):1076–84 DOI: https://doi.org/10.1111/cas.13930
Mazurek JM, Syamlal G, Wood JM, Hendricks SA, Weston A. Malignant mesothelioma mortality — United States, 1999–2015. MMWR Morb Mortal Wkly Rep [Internet]. 2017;66(8):214–8 DOI: https://doi.org/10.15585/mmwr.mm6608a3
Spirtas R, Heineman EF, Bernstein L, Beebe GW, Keehn RJ, Stark A, et al. Malignant mesothelioma: attributable risk of asbestos exposure. Occup Environ Med [Internet]. 1994;51(12):804–11 DOI: https://doi.org/10.1136/oem.51.12.804
Vivero M, Bueno R, Chirieac LR. Clinicopathologic and genetic characteristics of young patients with pleural diffuse malignant mesothelioma. Mod Pathol [Internet]. 2018;31(1):122–31 DOI: https://doi.org/10.1038/modpathol.2017.108
Moran CA, Albores-Saavedra J, Suster S. Primary peritoneal mesotheliomas in children: a clinicopathological and immunohistochemical study of eight cases. Histopathology [Internet]. 2008;52(7):824–30 DOI: https://doi.org/10.1111/j.1365-2559.2008.03029.x
Noone AM, Cronin KA, Altekruse SF, Howlader N, Lewis DR, Petkov VI, et al. Cancer incidence and survival trends by subtype using data from the surveillance epidemiology and end results program, 1992-2013. Cancer Epidemiology and Prevention Biomarkers. 2017;26:632–41 DOI: https://doi.org/10.1158/1055-9965.EPI-16-0520
Teta MJ, Mink PJ, Lau E, Sceurman BK, Foster ED. US mesothelioma patterns 1973-2002: indicators of change and insights into background rates. Eur J Cancer Prev [Internet]. 2008;17(6):525–34 DOI: https://doi.org/10.1097/CEJ.0b013e3282f0c0a2
Thomas A, Chen Y, Yu T, Gill A, Prasad V. Distinctive clinical characteristics of malignant mesothelioma in young patients. Oncotarget [Internet]. 2015;6(18):16766–73 DOI: https://doi.org/10.18632/oncotarget.4414
Sugarbaker DJ, Wolf AS, Chirieac LR, Godleski JJ, Tilleman TR, Jaklitsch MT, et al. Clinical and pathological features of three-year survivors of malignant pleural mesothelioma following extrapleural pneumonectomy. Eur J Cardiothorac Surg [Internet]. 2011;40(2):298–303 DOI: https://doi.org/10.1016/j.ejcts.2010.12.024
Carbone M, Adusumilli PS, Alexander HR Jr, Baas P, Bardelli F, Bononi A, et al. Mesothelioma: Scientific clues for prevention, diagnosis, and therapy. CA Cancer J Clin [Internet]. 2019;69(5):402–29 DOI: https://doi.org/10.3322/caac.21572
Hassan R, Morrow B, Thomas A, Walsh T, Lee MK, Gulsuner S, et al. Inherited predisposition to malignant mesothelioma and overall survival following platinum chemotherapy. Proc Natl Acad Sci U S A [Internet]. 2019;116(18):9008–13 DOI: https://doi.org/10.1073/pnas.1821510116
Loharamtaweethong K, Puripat N, Aoonjai N, Sutepvarnon A, Bandidwattanawong C. Anaplastic lymphoma kinase (ALK) translocation in paediatric malignant peritoneal mesothelioma: a case report of novel ALK-related tumour spectrum. Histopathology [Internet]. 2016;68(4):603–7 DOI: https://doi.org/10.1111/his.12779
Schumann SO, Kocher G, Minervini F. Epidemiology, diagnosis and treatment of the malignant pleural mesothelioma, a narrative review of literature. J Thorac Dis [Internet]. 2021;13(4):2510–23 DOI: https://doi.org/10.21037/jtd-20-2761
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Raza Ullah , Imranullah Khan , Shahida Naz , Aamir Ahmad , Haleema
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
