Histopathological Study of Post-Surgical Gallbladder to Establish True Histopathology Proven Chronic Inflammation
DOI:
https://doi.org/10.37762/jgmds.8-3.189Keywords:
Cholelithiasis, Chronic Cholecystitis, Cholecystectomy, Rokitansky-Aschoff sinusesAbstract
OBJECTIVES:
The aim of this study was to establish true histopathology proven diagnosis of chronic cholecystitis.
METHODOLOGY:
A cross-sectional study was conducted on 51 post-surgical gallbladders was done to assess their histopathological patterns in a single centered tertiary care hospital. The specimens were studied for chronic cholecystitis, fibrosis, hypertrophy and presence of Rokitansky-Aschoff sinuses. Descriptive analysis was done and associations of the histopathological changes with demographic data of patients were analyzed through Chi-squared test.
RESULTS:
Fifty-one post cholecystectomy samples of gallbladder were analyzed for histopathological changes with 82.4% showing chronic cholecystitis, 84.3% fibrosis, 64.7% congestion, and more than 60% mild or moderate hypertrophy. Moreover, 49% of the specimens showed Rokitansky-Aschoff sinuses. All these changes suggest chronic inflammation.
CONCLUSION:
Chronic cholecystitis, fibrosis, and Rokitansky-Aschoff sinuses are the most common histopathological findings in specimens of patients undergone cholecystectomy for cholelithiasis.
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Afghani E, Lo SK, Covington PS, Cash BD, Pandol SJ. Sphincter of Oddi function and risk factors for dysfunction. Front Nutr. 2017;4:1 DOI: https://doi.org/10.3389/fnut.2017.00001
Wang CC, Tsai MC, Sung WW, Yang TW, Chen HY, Wang YT, et al. Risk of cholangiocarcinoma in patients undergoing therapeutic endoscopic retrograde cholangiopancreatography or cholecystectomy: a population based study. World J Gastrointest Oncol. 2019;11(3):238 DOI: https://doi.org/10.4251/wjgo.v11.i3.238
Tanaja J, Lopez RA, Meer JM. Cholelithiasis. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021
Navuluri R, Hoyer M, Osman M, Fergus J. Emergent treatment of acute cholangitis and acute cholecystitis. Semin Intervent Radiol. 2020;37(1):14-23 DOI: https://doi.org/10.1055/s-0039-3402016
Afamefuna S, Allen SN. Gallbladder disease: pathophysiology, diagnosis, and treatment. US Pharm. 2013;38(3):33-41
Bansal A, Akhtar M, Bansal A. A clinical study: prevalence and management of cholelithiasis. Int Surg J. 2014;1(3):134 DOI: https://doi.org/10.5455/2349-2902.isj20141105
Tan Z, Xie P, Qian H, Yao X. Clinical analysis of prophylactic cholecystectomy during gastrectomy for gastric cancer patients: a retrospective study of 1753 patients. BMC Surg. 2019;19(1):1-7 DOI: https://doi.org/10.1186/s12893-019-0512-x
Histopathology of Gallbladder After Cholecystectomy [Internet]. Available from:https://www.medscape.com/viewarticle/810696_2
Khan MM, Mohammed AT, Behan RB, Yousif S. Frequency of gall bladder carcinoma among patients of cholelithiasis at tertiary care hospital. J Pharm Res Int. 2020:20-4 DOI: https://doi.org/10.9734/jpri/2020/v32i2130746
Terada T. Histopathologic features and frequency of gall bladder lesions in consecutive 540 cholecystectomies. Int J Clin Exp Pathol. 2013;6(1):91-6. Available from: www.ijcep.com
Rawla P, Sunkara T, Thandra KC, Barsouk A. Epidemiology of gallbladder cancer. J Clin Exp Hepatol. 2019;5(2):93 DOI: https://doi.org/10.5114/ceh.2019.85166
Butti AK, Yadav SK, Verma A, Das A, Naeem R, Chopra R, et al. Chronic calculus cholecystitis: is histopathology essential post-cholecystectomy?. Indian J Cancer. 2020;57(1):89 DOI: https://doi.org/10.4103/ijc.IJC_487_18
Sing A, Singh G, Kaur K, Goyal G, Saini G, Sharma D. Histopathological changes in gallbladder mucosa associated with cholelithiasis: a prospective study. Niger J Surg. 2019;25(1):21 DOI: https://doi.org/10.4103/njs.NJS_15_18
Suzuki T, Asahi Y, Sawada A, Umemoto K, Kina M, Shinohara M, et al. Laparoscopic cholecystectomy for a cholelithiasis patient with an aberrant biliary duct of B5: a case report. Surg Case Rep. 2020;6(1) DOI: https://doi.org/10.1186/s40792-020-00981-z
Khan DM, S.C A. Histopathological spectrum of gallbladder diseases in a tertiary care centre. IP Arch Cytol Histopathol Res. 2020;3(4):206-9 DOI: https://doi.org/10.18231/2456-9267.2018.0042
Hasan A, Nafie K, Aldossary MY, Ismail A, Monazea K, Baheeg M, et al. Unexpected histopathology results following routine examination of cholecystectomy specimens: how big and how significant?. Ann Med Surg. 2020;60:425-30 DOI: https://doi.org/10.1016/j.amsu.2020.11.019
Holanda AKG, Lima Júnior ZB. Gallbladder histological alterations in patients undergoing cholecystectomy for cholelithiasis. Rev Col Bras Cir. 2019;46(6):1-8 DOI: https://doi.org/10.1590/0100-6991e-20192279
Jha V, Sharma P, Mandal KA. Incidental gallbladder carcinoma: utility of histopathological evaluation of routine cholecystectomy specimens. South Asian J Cancer. 2018;7(1):21 DOI: https://doi.org/10.4103/2278-330X.226802
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