Frequency of Hyperlipidemia in the Diagnosed Type 2 Diabetic Patients
DOI:
https://doi.org/10.37762/jgmds.8-1.122Keywords:
Hyperlipidemia, Hypertriglyceridemia, HypercholesterolemiaAbstract
OBJECTIVES:
The primary event in the development of type-2 diabetes is directly associated with lipid metabolism derangement occurring due to insulin resistance. The aim of this study was to find out the prevalence of hyperlipidemia in the newly diagnosed type-2 DM.
METHODOLOGY:
This hospital based descriptive study was conducted in the year 2018 to 2019, on 100 newly diagnosed type-2 diabetic patients attending medical O.P.D or admitted in medial wards of Naseer Ullah Khan Babar Memorial Hospital Kohat Road Peshawar.
RESULTS:
The incidence of hyperlipidemia in newly diagnosed diabetic patients was 29%. About 71% patients were having normal lipid profile. Our study also revealed that the frequency of hyperlipidemia increases with age. Half of the patients having age more than 60 years developed hyperlipidemia. Among hyperlipidemic patients, hypercholesterolemia was present in 36% and hypertriglyceridemia in 64% patients
CONCLUSION:
The study suggests that hyperlipidemia is very common in newly diagnosed type-2 diabetic patients in this part of the world.
Downloads
Metrics
References
Raz I, Eldor R, Cernea S, Shafrir E. Diabetes: insulin resistance and derangements in lipid metabolism. Cure through intervention in fat transport and storage. Diabetes/Metab Res Rev. 2005;21(1):3-14 DOI: https://doi.org/10.1002/dmrr.493
Ozder A. Lipid profile abnormalities seen in T2DM patients in primary healthcare in Turkey: a cross-sectional study. Lipids Health Dis. 2014;13(1):183 DOI: https://doi.org/10.1186/1476-511X-13-183
Sosale A, Kumar KP, Sadikot S, Nigam A, Bajaj S, Zargar A, et al. Chronic complications in newly diagnosed patients with type 2 diabetes mellitus in India. Indian J Endocrinol Metab. 2014;18(3):355 DOI: https://doi.org/10.4103/2230-8210.131184
Williams R, Van Gaal L, Lucioni C. Assessing the impact of complications on the costs of Type II diabetes. Diabetologia. 2002;45(1):S13-S7 DOI: https://doi.org/10.1007/s00125-002-0859-9
Testa R, Olivieri F, Sirolla C, Spazzafumo L, Rippo M, Marra M, et al. Leukocyte telomere length is associated with complications of type 2 diabetes mellitus. Diabetic Med. 2011;28(11):1388-94 DOI: https://doi.org/10.1111/j.1464-5491.2011.03370.x
Krššák M, Winhofer Y, Göbl C, Bischof M, Reiter G, Kautzky-Willer A, et al. Insulin resistance is not associated with myocardial steatosis in women. Diabetologia. 2011;54(7):1871-8 DOI: https://doi.org/10.1007/s00125-011-2146-0
Haffner SM, D'Agostino R, Mykkänen L, Tracy R, Howard B, Rewers M, et al. Insulin sensitivity in subjects with type 2 diabetes. Relationship to cardiovascular risk factors: the Insulin Resistance Atherosclerosis Study. Diabetes Care. 1999;22(4):562-8 DOI: https://doi.org/10.2337/diacare.22.4.562
Hansen KB, Vilsbøll T, Bagger JI, Holst JJ, Knop FK. Increased postprandial GIP and glucagon responses, but unaltered GLP-1 response after intervention with steroid hormone, relative physical inactivity, and high-calorie diet in healthy subjects. J Clin Endocrinol Metab. 2011;96(2):447-53 DOI: https://doi.org/10.1210/jc.2010-1605
Wheeler E, Barroso I. Genome-wide association studies and type 2 diabetes. Briefings Funct Genomics. 2011;10(2):52-60 DOI: https://doi.org/10.1093/bfgp/elr008
Billings LK, Florez JC. The genetics of type 2 diabetes: what have we learned from GWAS?. Ann NY Acad Sci. 2010;1212:59-77 DOI: https://doi.org/10.1111/j.1749-6632.2010.05838.x
Diabetes AATFoI. American College of Endocrinology and American Diabetes Association consensus statement on inpatient diabetes and glycemic control. Endocrine Practice. 2006;12(4):458-68 DOI: https://doi.org/10.4158/EP.12.4.458
Heydari I, Radi V, Razmjou S, Amiri A. Chronic complications of diabetes mellitus in newly diagnosed patients. Int J Diabetes Mellitus. 2010;2(1):61-3 DOI: https://doi.org/10.1016/j.ijdm.2009.08.001
Harris MI. Hypercholesterolemia in diabetes and glucose intolerance in the US population. Diabetes Care. 1991;14(5):366-74 DOI: https://doi.org/10.2337/diacare.14.5.366
Ning F, Pang Z, Dong Y, Gao W, Nan H, Wang S, et al. Risk factors associated with the dramatic increase in the prevalence of diabetes in the adult Chinese population in Qingdao, China. Diabetic Med. 2009;26(9):855-63 DOI: https://doi.org/10.1111/j.1464-5491.2009.02791.x
Soebardi S, Purnamasari D, Oemardi M, Soewondo P, Waspadji S, Soegondo S. Dyslipidemia in newly diagnosed diabetes mellitus: the Jakarta primary non-communicable disease risk factors surveillance 2006. Acta Med Indones. 2009;41(4):186-90
Burchfiel CM, Abbott RD, Sharp DS, Curb JD, Rodriguez BL, Yano K. Distribution and correlates of lipids and lipoproteins in elderly Japanese-American men: the Honolulu Heart Program. Arterioscler Thromb Vasc Biol. 1996;16(11):1356-64 DOI: https://doi.org/10.1161/01.ATV.16.11.1356
Wu JY, Duan XY, Li L, Dai F, Li YY, Li XJ, et al. Dyslipidemia in Shanghai, China. Prev Med. 2010;51(5):412-5 DOI: https://doi.org/10.1016/j.ypmed.2010.08.013
Bhambhani G, Bhambhani RG, Thakor NC. Lipid profile of patients with diabetes mellitus: a cross sectional study. Int J Res Med Sci. 2015;3(11):3292-5 DOI: https://doi.org/10.18203/2320-6012.ijrms20151179
Kilim SR, Chandala SR. A comparative study of lipid profile and oestradiol in pre-and post-menopausal women. J Clin Diagn Res. 2013;7(8):1596-8 DOI: https://doi.org/10.7860/JCDR/2013/6162.3234
Humayun A, Shah AS, Alam S, Hussein H. Relationship of body mass index and dyslipidemia in different age groups of male and female population of Peshawar. J Ayub Med Coll Abbottabad. 2009;21(2):141-4
Cobbe SM. Baseline risk factors and their association with outcome in the West of Scotland Coronary Prevention Study. Am J Cardiol. 1997;79(6):756-62 DOI: https://doi.org/10.1016/S0002-9149(96)00863-6
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 Shama Iqbal, Dr., Ambreen Gul, Dr., Rashid Ahmad, Dr., Momina Haq, Dr., Sara Maryam, Dr., Safia Rehman, Dr.
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
