Systemic Juvenile idiopathic arthritis in child complicated by amyloidosis with secondary nephrotic syndrome
DOI:
https://doi.org/10.37762/jgmds.11-2.564Keywords:
Juvenile Idiopathic Arthritis, Secondary Nephrotic Syndrome, Amyloidosis, TocilizumabAbstract
A 7 years old girl diagnosed as case of juvenile idiopathic arthritis since the age of 1.5 years, generalized onset with systemic presentation is complicated by secondary nephrotic syndrome. Renal biopsy showing amyloidosis. Patient has severe disease course being complicated by sever flare ups of disease symptoms and body swelling. Since onset of disease patient got NSAIDs, methotrexate, steroids, anti TNF inhibitors with no or partial response. After diagnosis with secondary nephrotic syndrome due to secondary amyloidosis patient is started on intravenous tocilizumab. There is improvement of patient symptoms.
Downloads
Metrics
References
Palman J, Shoop-Worrall S, Hyrich K, McDonagh JE. Update on the epidemiology, risk factors and disease outcomes of Juvenile idiopathic arthritis. Best Pract Res Clin Rheumatol 2018;32(2):206-22 DOI: https://doi.org/10.1016/j.berh.2018.10.004
Di Ludovico A, La Bella S, Di Donato G, Felt J, Chiarelli F, Breda L. The benefits of physical therapy in juvenile idiopathic arthritis. Rheumatol Int 2023;43(9):1563-72 DOI: https://doi.org/10.1007/s00296-023-05380-9
Okamoto N, Yokota S, Takei S, Okura Y, Kubota T, Shimizu M, et al. Clinical practice guidance for juvenile idiopathic arthritis (JIA) 2018. Mod Rheumatol 2019;29(1):41-59 DOI: https://doi.org/10.1080/14397595.2018.1514724
Barišić Kutija M, Perić S, Knežević J, Juratovac Z, Vukojević N. Complication and prognosis of juvenile idiopathic arthritis associated uveitis in the era of modern immunomodulatory treatment. Psychiatr Danub 2019;31(Suppl 1):44-49
Cafarotti A, Marcovecchio ML, Lapergola G, Di Battista C, Marsili M, Basilico R, et al. Kidney function and renal resistive index in children with juvenile idiopathic arthritis. Clin Exp Med 2023;23(3):759-66 DOI: https://doi.org/10.1007/s10238-022-00898-x
Delplanque M, Pouchot J, Ducharme-Bénard S, Fautrel BJ, Benyamine A, Daniel L, et al. AA amyloidosis secondary to adult onset Still's disease: About 19 cases. Semin Arthritis Rheum 2020;50(1):156-65 DOI: https://doi.org/10.1016/j.semarthrit.2019.08.005
Kwiatkowska M, Jednacz E, Rutkowska-Sak L. Juvenile idiopathic arthritis complicated by amyloidosis with secondary nephrotic syndrome - effective treatment with tocilizumab. Reumatologia. 2015;53(3):157-60 DOI: https://doi.org/10.5114/reum.2015.53138
Mangal V, Datt B, Hegde A, Kashif AW, Kumar A, Kaur J, et al. Childhood-onset enthesitis-related arthritis leading to nephrotic syndrome due to secondary amyloidosis complicated by acute pulmonary embolism - The domino effect. Indian J Rheumatol 2022;17:180-5 DOI: https://doi.org/10.4103/injr.injr_160_21
Borysova T, Samsonenko S, Badogina L, Makoviichuk O. Renal Lesions of Juvenile Idiopathic Arthritis in Chidren: A Literature Review. Glob J Pediatr 2021;1(2):1008 DOI: https://doi.org/10.54026/GJP/1008
Cope AP, Aderka D, Doherty M, Engelmann H, Gibbons D, Jones AC, et al. Increased levels of soluble tumor necrosis factor receptors in the sera and synovial fluid of patients with rheumatic diseases. Arthritis Rheum 1992;35(10):1160-9 DOI: https://doi.org/10.1002/art.1780351008
Gupta A, Bagri NK, Tripathy SK, Barwad A, Phulware RH, Hari P, et al. Successful use of tocilizumab in amyloidosis secondary to systemic juvenile idiopathic arthritis Rheumatology International volume 40, pages153-159 (2020 DOI: https://doi.org/10.1007/s00296-019-04363-z
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Syed Sajid Hussain Shah, Bibi Aalia
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
