Race of GLPS: Impact on Weight and Glycemic Control on Type 2 Diabetes with Semaglutide Versus Liraglutide

Noha Hafeez; Fatima Jehanghir; Aroosa  Altaf; Huma  Akbar Jafri; Tariq  Adnan; Faiza Rani Ahmed; Naureen Kazim

doi:10.37762/jgmds.12-1.633

Authors

Noha Hafeez Ziauddin University, Medilink consultant clinic, Karachi
Fatima Jehanghir Ziauddin University, Medilink Consultant Clinic, Karachi
Aroosa Altaf Ziauddin University, Karachi
Huma Akbar Jafri Ziauddin University, Karachi First Peek Ultrasound Clinic, Calgary , AB, Canada
Tariq Adnan Ziauddin University, Karachi
Faiza Rani Ahmed Ziauddin University, Family Medicine Clinic, Karachi
Naureen Kazim Ziauddin University, Consultant Family Physician Doctor’s Plaza, Karachi

DOI:

https://doi.org/10.37762/jgmds.12-1.633

Keywords:

Semaglutide, Liraglutide, Weight loss, Glycemic control

Abstract

OBJECTIVES

Semaglutide is a glucagon-like peptide-1 receptor agonist that improves glycemic control and reduces body weight in patients with type 2 diabetes. This study aimed to evaluate the effect of Semaglutide with standard Metformin on glycemic control and BMI after 3 and 6 months of treatment. Additionally, we compared the glycemic control and weight benefits of Semaglutide vs. liraglutide.

METHODOLOGY

This longitudinal cohort study was conducted in a general practice clinic in Clifton and a family medicine health center in Ziauddin University, Karachi from April 2022 till April 2023. We enrolled 128 patients with type 2 diabetes who were treated with metformin alone. Patients received Semaglutide 2mg once weekly in addition to standard metformin 1gm bid for 6 months. HbA1C and BMI were measured at baseline, 3 months, and 6 months. We compared the glycemic control and weight loss of Semaglutide with a cohort of participants taking Liraglutide over a period of 6 months in the same catchment area in 2021 to determine which drug has an edge over the other.
RESULTS
Semaglutide was superior to Liraglutide in controlling sugars (HbA1c% reduction 1.13 vs 0.94) as well as in weight loss (10.6 vs 6.2kg) respectively. Single sample t-test showed a statistically significant difference from the hypothetical mean of HbA1C <6.5% (p-value <0.00) Paired t-test showed a strong correlation between initial weight and after 6 months’ weight and HbA1C respectively. (p-value <0.00 & 0.004).

CONCLUSION

Semaglutide has proven to be substantially beneficial in reducing weight (10.6kgs) and achieving optimal glycemic control (1.13% HbA1C reduction) over the 6-month study period. Semaglutide is superior to Liraglutide in controlling sugars and weight.

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Author Biographies

Noha Hafeez, Ziauddin University, Medilink consultant clinic, Karachi

Department of Family Medicine,
Resident Diploma In Family Medicine( DFM),
Ziauddin University, Medilink consultant clinic, Karachi

Fatima Jehanghir, Ziauddin University, Medilink Consultant Clinic, Karachi

Department of Family Medicine,
Professor, Consultant Family Physician,
Ziauddin University, Medilink Consultant Clinic, Karachi

Aroosa Altaf, Ziauddin University, Karachi

Department of Family Medicine,
Senior Registrar in Family Medicine,
Ziauddin University, Karachi

Huma Akbar Jafri, Ziauddin University, Karachi First Peek Ultrasound Clinic, Calgary , AB, Canada

Department of Family Medicine,
Resident Diploma of Family Medicine,
Ziauddin University, Karachi first Peek Ultrasound Clinic, Calgary , AB, Canada

Tariq Adnan, Ziauddin University, Karachi

Department of Family Medicine,
Resident Diploma Family Medicine,
Ziauddin University, Karachi

Faiza Rani Ahmed, Ziauddin University, Family Medicine Clinic, Karachi

Department of Family Medicine,
Resident Diploma of Family Medicine,
Ziauddin University, Family Medicine Clinic, Karachi

Naureen Kazim, Ziauddin University, Consultant Family Physician Doctor’s Plaza, Karachi

Department of Family Medicine,
Senior Registrar in Family Medicine,
Ziauddin University. Consultant Family Physician Doctor’s Plaza, Karachi

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