Frequency and Risk Factors Associated with Positive Cases of Hepatitis B and Hepatitis C in 100 Dialysis Dependent Patients
DOI:
https://doi.org/10.37762/jgmds.2-1.57Keywords:
Dialysis, nephropathy and sterilizationAbstract
The main objective of the study was to determine the frequency of hepatitis B and hepatitis C in hemodialysis dependent patients who are positive for either type of hepatitis infection.
Methodology:
Study was conducted for duration of five months (1st Dec 2014- 23rd April 2015) at nephrology unit of Khyber teaching hospital and kidney center of Hayat Abad medical complex. Patients who were dependent on dialysis with renal failure due to any cause were targeted for the study. All patients who were found positive for either type of hepatitis infection were included in the study. All patients who were positive with hepatitis infection before the start of dialysis and those who came for the first time for dialysis were excluded from the study.A semi structured questionnaire with both open and close ended questions was used to collect the information from the patients. Written consent was taken from all the patients prior to the data collection after explaining purpose of the study. It was a cross sectional study and non-probability convenient sampling technique was adopted for the data collection. Total of hundred patients who were positive for hepatitis were taken as sample size. Patient’s record was also thoroughly checked as an adding tool for data collection. Apart from patients some inquiry was also done from the concerned staff working on dialysis machines.
Results:
Results of this study show that the prevalence of hepatitis infection is more in dialysis dependent patients as compared to the general population, and that among the positive cases the frequency of hepatitis C was more than hepatitis B. Common risk factors associated with increase prevalence of hepatitis infection among hemodialysis dependent patients are frequent blood transfusion without proper screening, lack of proper sterilization of dialysis machine and environment where dialysis is carried out. Close proximity of the patients with positive cases of hepatitis positive patients, previous surgical procedures carried out, history of hepatitis infection in family and decreased immunity of the dialysis patients
Conclusions:
Frequent dialysis leads to increase frequency of hepatitis C as compared to hepatitis B and unsterilized environment of the area around the machine and unscreened blood transfusion are the major contributors.
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References
Pereiva BJ, Levey As. Hepatitis C Virus Infection in dialysis and renal transplantation. Kidney international; 1997:51:1981-1999 DOI: https://doi.org/10.1038/ki.1997.139
Thumas V. Viral Hepatitis infection among dialysis patients. Registry report nephrology; 2007; 12:399-405 DOI: https://doi.org/10.1111/j.1440-1797.2007.00815.x
Etymonline.com. Retrieved; 2012-08-26
Palevsky P. Renal replacement therapy 1: Indications and timing, critical care clinics; 2005, Elsevier Saunders, 348 DOI: https://doi.org/10.1016/j.ccc.2004.12.002
Krause R, Schraga E. Dialysis Complications of chronic renal failure, Medscape; 2013, 1-4
Hutin YJ, Goldstein ST, Varma JK, O'Dair JB, Mast EE, Shapiro CN, Alter MJ. An outbreak of hospital-acquired hepatitis B virus infection among patients receiving chronic hemodialysis. Infect Control HospEpidemiol 1999; 20: 731-735 DOI: https://doi.org/10.1086/501573
Jankovic N, Cala S, Nadinic B, Varlaj-Knobloch V, Pavlovic D. Hepatitis C and hepatitis B virus infection in hemodialysis patients and staff: a two year follow-up. Int J Artif Organs 1994; 17: 137-140 DOI: https://doi.org/10.1177/039139889401700302
Hinrichsen H, Leimenstoll G, Stegen G, Schrader H, Folsch UR, and Schmidt WE: Prevalence and risk factors of hepatitis C virus infection in haemodialysis patients: a multicentre study in 2796 patients. Gut 2002, 51(3):429-433 DOI: https://doi.org/10.1136/gut.51.3.429
Hitzler WE, Runkel S: Routine HCV PCR screening of blood donations to identify early HCV infection in blood donors lacking antibodies to HCV. Transfusion 2001, 41(3):333-337 DOI: https://doi.org/10.1046/j.1537-2995.2001.41030333.x
Pereira BJ: Hepatitis C infection and post-transplantation liver disease. Nephron Dial Transplant 1995, 10(Suppl 1):58-67 DOI: https://doi.org/10.1093/ndt/10.supp1.58
Ali S. Donahue MJ. Qureshi H, prevalence of HBV and HCV and risk factors in Pakistan, International Journal of infectious diseases; 1st January 2010
Mondelli MU, Smedile V, Piazza V. Abnormal alanine aminotransferase activity reflects the exposure to hepatitis C virus in hemodialysis patients. Nephron Dial Transplant 1991:6:480-3 DOI: https://doi.org/10.1093/ndt/6.7.480
Alashek WA, McIntyre CW, Taal MW: Determinants of survival in patients receiving dialysis in Libya
54. Yakaryilmaz F, Gurbuz OA, Guliter S, Mert A, Songur Y, Karakan T, Keles H: Prevalence of occult hepatitis B and hepatitis C virus infections in Turkish hemodialysis patients. Ren Fail 2006, 28(8):729-735 DOI: https://doi.org/10.1080/08860220600925602
Batieha A, Abdallah S, Maghaireh M, Awad Z, Al-Akash N, Batieneh A, AjlouniKA:Epidemiology and cost of haemodialysis in Jordan. East Mediterr Health J 2007, 13(3):654-663
Ferreira RC, Teles SA, Dias MA, Tavares VR, Silva SA, Gomes SA, Yoshida CF, Martins RM: Hepatitis B virus infection profile in hemodialysis patients in Central Brazil: prevalence, risk factors, and genotypes. MemInstOswaldo Cruz 2006, 101(6):689-692 DOI: https://doi.org/10.1590/S0074-02762006000600019
Chandra M, Khaja MN, Hussain MM, Poduri CD, Farees N, Habeeb MA, Krishnan S, Ramareddy GV, Habibullah CM: Prevalence of hepatitis B and hepatitis C viral infections in Indian patients with chronic renal failure. Intervirology 2004, 47(6):374-376 DOI: https://doi.org/10.1159/000080883
Salwa S, Hayder A, Hayder S, KutherH.Viral hepatitis infections in Basrahhaemodialysis unit:Serological diagnosis and viral loading, European Journal of Experimental Biology. 2014; 4(2):106-112
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Copyright (c) 2015 Riaz Gul, Dr., Ahmad Zeb, Dr., Naila Sher, Dr.
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