Diagnostic Yield of Blood Cultures among Patients Admitted with Non-Focal Pyrexias
DOI:
https://doi.org/10.37762/jgmds.11-1.486Keywords:
Blood Culture, Non-Focal Pyrexias, Incubation, Escherichia ColiAbstract
OBJECTIVES
To establish the diagnostic yield of blood cultures among patients admitted with non-focal pyrexias.
METHODOLOGY
This descriptive cross-sectional study was conducted in the Department of Medicine, Khyber Teaching Hospital, Peshawar, from August 2020 to April 2021. One hundred ninety-seven patients with non-focal pyrexia were recruited. Data about age, gender, presence of other illnesses like diabetes and hypertension, history of smoking and duration of fever were noted. A thorough clinical evaluation was done. Under aseptic conditions, 2 blood culture sets were taken. The final blood culture report was collected after 5 days of incubation in culture media. The culture was labelled positive if any organism was isolated from the sample. All data was entered in specially designed proforma. Patients with positive blood cultures were managed as per hospital protocols. Confidentiality of data was ensured.
RESULTS
Our study shows that among 197 patients, 18(9%) had positive cultures, while 179(91%) did not yield any pathogen on blood culture. Escherichia coli was the most commonly grown organism among the positive blood cultures.
CONCLUSION
The yield of blood culture was 9% in febrile patients admitted to the medical ward of a tertiary care hospital.
Downloads
Metrics
References
Sullivan KV. Advances in diagnostic testing that impact infection prevention and antimicrobial stewardship programs. Curr Infect Dis Rep. 2019;21(6):20
Nazir A, Sana I, Peerzada BY, Farooq T. Study of prevalence and antimicrobial susceptibility pattern of blood culture isolates from a tertiary care hospital of North India. Int J Res Med Sci. 2018;6(12):4046-52
Neemann K, Yonts AB, Qiu F, Simonsen K, Lowas S, Freifeld A. Blood Cultures for Persistent Fever in Neutropenic Pediatric Patients Are of Low Diagnostic Yield. J Pediatric Infect Dis Soc. 2016;5(2):218-21
Grace CJ, Lieberman J, Pierce K, Littenberg B. Usefulness of blood culture for hospitalized patients who are receiving antibiotic therapy. Clin Infect Dis. 2001;32(11):1651-5
Maurer FP, Christner M, Hentschke M, Rohde H. Advances in rapid identification and susceptibility testing of bacteria in the clinical microbiology laboratory: implications for patient care and antimicrobial stewardship programs. Infect Dis Rep. 2017;9(1):6839
Kee PP, Chinnappan M, Nair A, Yeak D, Chen A, Starr M et al. Diagnostic yield of timing blood culture collection relative to fever. Pediatr Infect Dis J. 2016;35(8):846-50
Serody JS, Berrey MM, Albritton K, O’Brien SM, Capel EP, Bigelow SH, et al. Utility of obtaining blood cultures in febrile neutropenic patients undergoing bone marrow transplantation. Bone Marrow Transplant. 2000;26(5):533-8
Riedel S, Bourbeau P, Swartz B, Brecher S, Carroll KC, Stamper PD et al. Timing of specimen collection for blood cultures from febrile patients with bacteremia. J Clin Microbiol. 2008 Apr;46(4):1381-5
Nannan Panday RS, Wang S, van de Ven PM, Hekker TAM, Alam N, Nanayakkara PWB. Evaluation of blood culture epidemiology and efficiency in a large European teaching hospital. PLOS ONE. 2019 Mar 21;14(3):e0214052
Lamy B, Dargère S, Arendrup MC, Parienti JJ, Tattevin P. How to optimize the use of blood cultures for the diagnosis of bloodstream infections? A state-of-the art. Front Microbiol. 2016;7:697
Acestor N, Cooksey R, Newton PN, Ménard D, Guerin PJ, Nakagawa J et al. Mapping the aetiology of non-malarial febrile illness in Southeast Asia through a systematic review–terra incognita impairing treatment policies. PLOS ONE. 2012;7(9):e44269
From: The Indian Society of Critical Care Medicine Tropical fever Group, Singhi S, Chaudhary D, Varghese GM, Bhalla A, Karthi N et al. Tropical fevers: management guidelines. Indian J Crit Care Med. 2014;18(2):62-9
Reddy EA, Shaw AV, Crump JA. Community-acquired bloodstream infections in Africa: a systematic review and meta-analysis. Lancet Infect Dis. 2010;10(6):417-32
Singh R, Singh SP, Ahmad N. A study of etiological pattern in an epidemic of acute febrile illness during monsoon in a tertiary health care institute of Uttarakhand, India. J Clin Diagn Res. 2014;8(6):MC01-3
Zeretzke CM, McIntosh MS, Kalynych CJ, Wylie T, Lott M, Wood D. Reduced use of occult bacteremia blood screens by emergency medicine physicians using immunization registry for children presenting with fever without a source. Pediatr Emerg Care. 2012;28(7):640-5
Kasper MR, Blair PJ, Touch S, Sokhal B, Yasuda CY, Williams M et al. Infectious etiologies of acute febrile illness among patients seeking health care in south-central Cambodia. Am J Trop Med Hyg. 2012;86(2):246-53
Bryce A, Hay AD, Lane IF, Thornton HV, Wootton M, Costelloe C. Global prevalence of antibiotic resistance in paediatric urinary tract infections caused by Escherichia coli and association with routine use of antibiotics in primary care: systematic review and meta-analysis. BMJ. 2016 Mar 15;352:i939
Foong KS, Munigala S, Kern-Allely S, Warren DK. Blood culture utilization practices among febrile and/or hypothermic inpatients. BMC Infect Dis. 2022;22(1):779
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Aliena Badshah, Ahmed Naseer, Imran Ullah, Muhammad Ishaq
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.