Effect of Gender on the Outcome of Acute Coronary Syndrome in Type 2 Diabetes Mellitus

Authors

  • Afsheen Mahmood Khyber Girls Medical College, Peshawar
  • Kiramat Ullah Khan Peshawar Institute of Cardiology
  • Muhammad Iqbal PIMS, Islamabad
  • Junaid Ahmad Khan Sheikh Mohammed Bin Zayed Al Nayan Institute of Cardiology, Quetta
  • Shahid Ali Shah Faculté d'odontologie, France
  • Naveed Afzal Khan Khyber Girls Medical College, Peshawar

DOI:

https://doi.org/10.37762/jgmds.10-3.451

Keywords:

Acute coronary Syndrome, Type 2 Diabetes, Diabetes Mellitus

Abstract

OBJECTIVES

To determine the frequency of acute coronary syndrome presentations among diabetic patients and in-hospital outcomes based on gender variance.

METHODOLOGY

This observational cross-sectional study was conducted at the cardiology department of the Pakistan Institute of Medical Sciences, Islamabad. 106 consecutive diabetic patients with acute coronary syndrome were enrolled. Patients were assessed for in-hospital outcomes like congestive heart failure, recurrent angina, and mortality. The outcomes were evaluated based on gender. The Chi-Square test was used for significant differences keeping the P value < 0.05. 
RESULTS
The mean age of the patients was 57.75±8.16 years. Males were 57 (53.8%), and females were 49 (46.2%). Congestive heart failure, re-angina, and mortality were significant in both genders yielding a P value of <0.05.

CONCLUSION

Diabetes is an important predictor of acute coronary syndrome. The complications related to congestive heart failure and mortality are more prevalent in males than females.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Author Biographies

Afsheen Mahmood, Khyber Girls Medical College, Peshawar

FCPS, Assistant Professor, Department of Physiology,
Khyber Girls Medical College, Peshawar

 

Kiramat Ullah Khan , Peshawar Institute of Cardiology

FCPS, Senior Registrar,
Peshawar Institute of Cardiology

 

Muhammad Iqbal , PIMS, Islamabad

FCPS, Assistant Professor,
Department of Cardiac Surgery, PIMS, Islamabad

 

Junaid Ahmad Khan, Sheikh Mohammed Bin Zayed Al Nayan Institute of Cardiology, Quetta

FCPS, Assistant Professor, Department of Cardiac Surgery,  
Sheikh Mohammed Bin Zayed Al Nayan Institute of Cardiology, Quetta

 

Shahid Ali Shah, Faculté d'odontologie, France

PhD Scholar, Université de Montpellier,
Faculté d'odontologie, France

 

Naveed Afzal Khan, Khyber Girls Medical College, Peshawar

MHPE, Assistant Professor Medical Education,
Khyber Girls Medical College, Peshawar

 

References

Berstad P, Botteri E, Larsen IK, Løberg M, Kalager M, Holme Ø, et al. Lifestyle changes at middle age and mortality: a population-based prospective cohort study. J Epidemiol Community Health. 2017;71(1):59-66 DOI: https://doi.org/10.1136/jech-2015-206760

Grasgruber P, Sebera M, Hrazdira E, Hrebickova S, Cacek J. Food consumption and the actual statistics of cardiovascular diseases: an epidemiological comparison of 42 European countries. Food & nutrition research. 2016;60(1):31694 DOI: https://doi.org/10.3402/fnr.v60.31694

Stokes A, Preston SH. Deaths attributable to diabetes in the United States: comparison of data sources and estimation approaches. PloS one. 2017;12(1):e0170219 DOI: https://doi.org/10.1371/journal.pone.0170219

Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes care. 2004;27(5):1047-53 DOI: https://doi.org/10.2337/diacare.27.5.1047

Plakht Y, Gilutz H, Shiyovich A. Changes over Time in Hemoglobin A1C (HbA1C) Levels Predict Long-Term Survival Following Acute Myocardial Infarction among Patients with Diabetes Mellitus. Journal of Clinical Medicine. 2021;10(15):3232 DOI: https://doi.org/10.3390/jcm10153232

Chandrasekhar J, Gill A, Mehran R. Acute myocardial infarction in young women: current perspectives. International journal of women's health. 2018;10:267 DOI: https://doi.org/10.2147/IJWH.S107371

Khan E, Brieger D, Amerena J, Atherton JJ, Chew DP, Farshid A, et al. Differences in management and outcomes for men and women with ST‐elevation myocardial infarction. Medical Journal of Australia. 2018;209(3):118-23 DOI: https://doi.org/10.5694/mja17.01109

Anand A, Shah AS, Beshiri A, Jaffe AS, Mills NL. Global adoption of high-sensitivity cardiac troponins and the universal definition of myocardial infarction. Clinical chemistry. 2019;65(3):484-9. DOI: https://doi.org/10.1373/clinchem.2018.298059

Ali U, Ashraf A, Ahmad A. DIABETIC PATIENTS AND THEIR PRESENTATION IN ACUTE CORONARY SYNDROME WITH OUTCOMES: DOES GENDER PLAY ROLE? Pakistan Heart Journal. 2022;55(1):79-82 DOI: https://doi.org/10.47144/phj.v55i1.2158

Yu Y, Arah OA, Liew Z, Cnattingius S, Olsen J, Sørensen HT, et al. Maternal diabetes during pregnancy and early onset of cardiovascular disease in offspring: population based cohort study with 40 years of follow-up. Bmj. 2019;367 DOI: https://doi.org/10.1136/bmj.l6398

Seghieri G, Policardo L, Anichini R, Franconi F, Campesi I, Cherchi S, et al. The effect of sex and gender on diabetic complications. Current diabetes reviews. 2017;13(2):148-60 DOI: https://doi.org/10.2174/1573399812666160517115756

Xu J, Murphy S, Kochanek K, Bastian B, Arias E. Deaths: Final data for 2013 National vital statistics reports; vol 64 no 2. Hyattsville, MD: National Center for Health Statistics. 2016

Clemens K, Woodward M, Neal B, Zinman B, Cheruvath P. Sex disparities in cardiovascular outcome trials of diabetes populations: a systematic review and meta-analysis. Diabetes Care. 2020;45(5) DOI: https://doi.org/10.2337/dc19-2257

Babes EE, Bustea C, Behl T, Abdel-Daim MM, Nechifor AC, Stoicescu M, et al. Acute coronary syndromes in diabetic patients, outcome, revascularization, and antithrombotic therapy. Biomedicine & Pharmacotherapy. 2022;148:112772 DOI: https://doi.org/10.1016/j.biopha.2022.112772

Einarson TR, Acs A, Ludwig C, Panton UH. Prevalence of cardiovascular disease in type 2 diabetes: a systematic literature review of scientific evidence from across the world in 2007–2017. Cardiovascular diabetology. 2018;17(1):1-19 DOI: https://doi.org/10.1186/s12933-018-0728-6

Kim YH, Her A-Y, Jeong MH, Kim B-K, Hong S-J, Kim S, et al. Effects of stent generation on clinical outcomes after acute myocardial infarction compared between prediabetes and diabetes patients. Scientific reports. 2021;11(1):1-12 DOI: https://doi.org/10.1038/s41598-021-88593-x

Behl T, Sehgal A, Grover M, Singh S, Sharma N, Bhatia S, et al. Uncurtaining the pivotal role of ABC transporters in diabetes mellitus. Environmental Science and Pollution Research. 2021;28(31):41533-51 DOI: https://doi.org/10.1007/s11356-021-14675-y

Avogaro A, Bonora E, Consoli A, Del Prato S, Genovese S, Giorgino F. Glucose-lowering therapy and cardiovascular outcomes in patients with type 2 diabetes mellitus and acute coronary syndrome. Diabetes and Vascular Disease Research. 2019;16(5):399-414 DOI: https://doi.org/10.1177/1479164119845612

Shehab A, Al-Dabbagh B, Almahmeed W, Bustani N, Agrawal A, Yusufali A, et al. Characteristics, management, and in-hospital outcomes of diabetic patients with acute coronary syndrome in the United Arab Emirates. The Scientific World Journal. 2012;2012 DOI: https://doi.org/10.1100/2012/698597

Downloads

Published

2023-07-01

How to Cite

Mahmood, A., Khan , K. U. ., Iqbal , M. ., Khan, J. A. ., Shah, S. A. ., & Khan, N. A. (2023). Effect of Gender on the Outcome of Acute Coronary Syndrome in Type 2 Diabetes Mellitus. Journal of Gandhara Medical and Dental Science, 10(3), 69–72. https://doi.org/10.37762/jgmds.10-3.451

Most read articles by the same author(s)