Frequency of Dyslipidemia in Patients Having Subclinical Hypothyroidism
DOI:
https://doi.org/10.37762/jgmds.3-01.44Keywords:
dyslipidemia, subclinical, hypothyroidismAbstract
INTRODUCTION
Thyroid hormone by binding to the thyroid hormone receptors affects metabolism and growth in nearly all tissues of the body. Thyroid hormones play vital role in the synthesis and metabolism of lipids. The reduced secretion of thyroxine (T4) and triiodothyronine (T3) from the thyroid gland results in hypothyroidism. The subclinical hypothyroidism (SH) is term used for the condition in which there is small elevation of thyroid stimulating hormone (TSH) in the presence of normal thyroid hormone levels. Disorders of thyroid gland are the second most common endocrine abnormalities globally after diabetes mellitus.
OBJECTIVE
To determinethe frequency of dyslipidemia in patients having subclinical hypothyroidism.
METHODOLOGY
This study was conducted at Naseer Teaching Hospital, Peshawar. Duration of the study was one years and the study design was descriptive cross sectional study. The total sample size was 136 patients presenting with subclinical hypothyroidism taking 34.31% proportion of dyslipidemia in subclinical hypothyroid patients12, 95% confidence interval and 8 % margin of error; using WHO software for sample size calculation. More over consecutive (non-probability sampling) technique was used for sample collection.
RESULTS
In this study mean age was 40 years with SD 1.26. Sixty three percent patients were female and 37% patients were male. Seventy percent patients had dyslipidemia while 30% patients didn’t have dyslipidemia.
CONCLUSION
The current study shows that the incidence of dyslipidemia was found to be in patients having subclinical hypothyroidism.
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References
Marwaha RK, Tandon N , Garg MK, Kanwar R, Sastry A, Narang A, et al. Dyslipidemia in subclinical hypothyroidism in an Indian population. Clinical Biochemistry. 2011;44:1214–7 DOI: https://doi.org/10.1016/j.clinbiochem.2011.07.003
Saini V, Yadav A, Arora S, Singh R and Bhattacharjee J. Association between different degrees of hypothyroidism and serum lipids. Internet Journal of Medical Update. 2012;7(2):3-8
Regmi A, Shah B, Rai BR,Pandeya A. Serum lipid profile in patients with thyroid disorders in central Nepal. Nepal Med Coll J 2010;12(4):253-6
Arishma T, Ito M, Sasaki I, Hiraiwa T, Kubota S, Fukata S, et al. Effect of levothyroxine replacement on postprandial hyperlipidemia in patients with subclinical hypothyroidism. Bulletin of the Osaka Medical College. 2010;56(2):41-8
ShahbazianHB ,Behbahani AM, Mohtashami AZ. Prevalence of thyroid dysfunction and thyroid auto antibodies in type 2 diabetic patients. Pak J Med Sci. 2011;27(5):1169-72
Peppa M, Grigoria B, Dimitriades G. Lipid abnormalities and cardiometabolic risk in patients with overt and subclinical thyroid disease. Biomarker Insights. 2011 Article ID 575840 DOI: https://doi.org/10.1155/2011/575840
Biondi B, Cooper DS. The clinical significance of subclinical thyroid dysfunction.Endocr Rev. 2008;29:76–131 DOI: https://doi.org/10.1210/er.2006-0043
Jellinger PS, Smith DA, Mehta AE, Ganda O, Handelsman Y, Rodbard HW, et al.American association of clinical endocrinologists' guidelines for management of dyslipidemia and prevention of atherosclerosis. EndocrPrac.2012;18:1-78 DOI: https://doi.org/10.4158/EP.18.S1.1
Rizos CV, Elisaf MS, Liberopoulos EN. Effects of thyroid dysfunction on lipid profile. The Open Cardiovasc Med J.2011;5:76-84 DOI: https://doi.org/10.2174/1874192401105010076
Basharat Z, Mumtaz S, Rashid F, Rashid S, Mallam SA, Diljan A, et al. Prevalence of risk factors of ischemic stroke in a local Pakistani population. High-density lipoproteins, an emerging risk factor. Neurosciences.2012;17:357-62
Zhu X, Cheng SY. New insights into regulation of lipid metabolism by thyroid hormone. CurrOpinEndocrinol Diabetes Obes.2010;17(5):408-13 DOI: https://doi.org/10.1097/MED.0b013e32833d6d46
Lai Y, Wang J, Jiang F, Wang B, Chen Y, Li M, et al. The relationship between serum thyrotropin and components of metabolic syndrome. Endocr J.2011;58:23-30 DOI: https://doi.org/10.1507/endocrj.K10E-272
Saxena A, Kapoor P, Saxena S, Kapoor AK. Effect of levothyroxine therapy on dyslipidemia in hypothyroid patients.Internet Journal of Medical Update.2013;8(2):39-49
KhanA, Khan MMA, Akhtar S. Thyroid Disorders, Etiology and Prevalence. J Med Sci 2002;2:89-94 DOI: https://doi.org/10.3923/jms.2002.89.94
MacCarthy PA,Shah AM.Impaired endothelium-dependent regulation of ventricular relaxation in pressure-overload in cardiac hypertrophy. Circulation 2000;101:1854-61 DOI: https://doi.org/10.1161/01.CIR.101.15.1854
Al Sayed A, Al Ali N, Bo Abbas Y, Alfadhli E. Subclinical hypothyroidism is associated with early insulin resistance in Kuwaiti women. Endocrine Journal 2006;53:653-7 DOI: https://doi.org/10.1507/endocrj.K06-018
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Copyright (c) 2016 Shah Zeb, Dr., Shafaq Naz, Dr., Najeeb Ullah, Dr.
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