Role of Tri-Phasic Computed Tomography in Evaluation of Hepatocellular Carcinoma Patients with Liver Cirrhosis

Authors

  • Naila Tamkeen Hayatabad Medical Complex Peshawar
  • Ghazala Wahid Hayatabad Medical Complex Peshawhar
  • Adnan Ahmad Hayatabad Medical Complex Peshawar
  • Mehreen Samad Hayatabad Medical Complex Peshawar
  • Mahnoor Rehman Hayatabad Medical Complex Peshawar
  • Khushbakht Hayatabad Medical Complex Peshawar
  • Maimoona Afsar Hayatabad Medical Complex Peshawar

DOI:

https://doi.org/10.37762/jgmds.9-4.330

Keywords:

Cirrhosis, Hepatocellular Carcinoma (HCC), Tri-Phasic, Cirrhosis, Hepatocelular carcinoma (HCC), Tri-Phasic computed tomography

Abstract

OBJECTIVES
To assess the usefulness of Tri-phasic computed tomography in the evaluation of hepatocellular carcinoma in cirrhotic patients.

METHODOLOGY
This cross-sectional study was carried out in the Radiology and Imaging Department of Hayatabad Medical Complex Peshawar from October 2020 to September 2021 (01 year). Tri-phasic CT was done in all patients. Patients with suspected hepatocellular carcinoma diagnosed by clinical and ultrasonography and having high serum α-fetoprotein levels were enrolled in the study.

RESULTS
Malignant cases on tri-phasic CT were 120(82.8%) while benign cases were 25 (17.2%) Fig -I. In malignant tumor cases, 99(82.5%) patients had hepatocellular carcinoma (HCC), 13(10.8%) had metastases and 8(6.7%) had dysplastic nodule respectively. In benign tumour cases, 15(60%) had regenerative nodules, 6(24%) had hepatic adenoma and 4 (16%) had haemangioma. Tri -phasic CT as a tool in the diagnosis of hepatocellular carcinoma in cirrhotic patients showed a sensitivity of 96.8%, specificity of 79.7%, the accuracy of 95%, positive predictive values of 96.2% and negative predictive values of 88.1%.

CONCLUSION
Tri-Phasic CT can be an ideal diagnostic tool for detecting as well as characterizing hepatocellular carcinoma in cirrhotic patients.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Author Biographies

Naila Tamkeen, Hayatabad Medical Complex Peshawar

Assistant Professor, Department of Radiology
Hayatabad Medical Complex Peshawar

Ghazala Wahid, Hayatabad Medical Complex Peshawhar

Assistant Professor, Department of Radiology,
Hayatabad Medical Complex Peshawar

Mehreen Samad, Hayatabad Medical Complex Peshawar

Associate Professor, Department of Radiology,
Hayatabad Medical Complex Peshawar

Mahnoor Rehman, Hayatabad Medical Complex Peshawar

Assistant Professor, Department of Radiology,
Hayatabad Medical Complex Peshawar

Khushbakht, Hayatabad Medical Complex Peshawar

Specialist Registrar, Department of Radiology,
Hayatabad Medical Complex Peshawar

Maimoona Afsar, Hayatabad Medical Complex Peshawar

Specialist Registrar, Department of Radiology,
Hayatabad Medical Complex Peshawar

References

Abbas KA, Caroline AE, Edward R. Triple phase CT Hounsfield & pattern in differentiation of liver lesions. Journal of Dental & Medical Sciences. 2017;16 (01):120-25

Kamlesh G, Neelam G, Garima R. Role of computed tomography in evaluation of parenchymal lesions of liver. Journal of Medical & Dental Sciences. 2015;4 (36):6257-68

Divya B, Reena M, Avinash G, Sumitra C, Jaya P. Role of triple phase CT in [12] the evaluation of liver lesions. International Journal of Current Research. 2017;9(03):48075-78

Best LM, Rawji V, Pereira SP, Davidson BR, Gurusamy KS. Imaging modalities for characterising focal pancreatic lesions. Cochrane Database of Systematic Reviews. 2017(4).

Rashed WM, Kandeil MA, Mahmoud MO, Ezzat S. Hepatocellular Carcinoma (HCC) in Egypt: A comprehensive overview. Journal of the Egyptian National Cancer Institute. 2020 Dec;32(1):1-1

Violi F, Corazza GR, Caldwell SH, Talerico G, Romiti GF, Napoleone L, Perticone F, Bolondi L, Pietrangelo A, Vestri AR, Raparelli V. Incidence and recurrence of portal vein thrombosis in cirrhotic patients. Thrombosis and Haemostasis. 2019 Mar;119(03):496-9

Kovac JD, Ivanovic A, Milovanovic T, Micev M, Alessandrino F, Gore RM. An overview of hepatocellular carcinoma with atypical enhancement pattern: spectrum of magnetic resonance imaging findings with pathologic correlation. Radiology and Oncology. 2021 Jun 1;55(2):130-43

Limsrivilai J, Srisajjakul S, Pongprasobchai S, Leelakusolvong S, Tanwandee T. A prospective blinded comparison of video capsule endoscopy versus computed tomography enterography in potential small bowel bleeding. Journal of Clinical Gastroenterology. 2017 Aug 1;51(7):611-8

Smith C, Hartsough RW, Spieler B, Dickerson T, Hudson C, Lopez F, Marshall R, Riker A. A 44-Year-Old Woman with Abdominal Pain Giant Pedunculated Cavernous Hepatic Hemangioma. J La State Med Soc. 2018 Jul;170:125

Kelly EM, Feldstein VA, Parks M, Hudock R, Etheridge D, Peters MG. An assessment of the clinical accuracy of ultrasound in diagnosing cirrhosis in the absence of portal hypertension. Gastroenterology & hepatology. 2018 Jun;14(6):367

Barkhof F, Jager R, Thurnher M, Cañellas AR, editors. Clinical neuroradiology: the ESNR textbook. Springer International Publishing; 2019

Seifeldein GS, Hassan EA, Imam HM, Makboul R, Idriss NK, Gaber MA, Elkady RM. Quantitative MDCT and MRI assessment of hepatic steatosis in genotype 4 chronic hepatitis C patients with fibrosis. Egyptian Journal of Radiology and Nuclear Medicine. 2021 Dec;52(1):1-4

Guo W, Qi Y, Zhang Y, Ma L, Yu D, Zhan J. Biocompatible caramelized carbonaceous nanospheres supported paramagnetic ultrathin manganese oxide nanosheets via self-sacrificing reduction as a MRI contrast agent for liver imaging. Carbon. 2016 Dec 1;110:321-9

Inoue A, Uemura R, Takaki K, Sonoda A, Ota S, Nitta N, Batsaikhan B, Takahashi H, Watanabe Y. Clinical impact of low tube voltage computed tomography during hepatic arteriography with low iodine to detect hepatocellular carcinoma before transarterial chemoembolization. European Journal of Radiology. 2022 Sep 1;154:110420

Roberts LR, Sirlin CB, Zaiem F, Almasri J, Prokop LJ, Heimbach JK, Murad MH, Mohammed K. Imaging for the diagnosis of hepatocellular carcinoma: A systematic review and meta‐analysis. Hepatology. 2018 Jan;67(1):401-21

Zafar W, Zulfiqar Z, Din NU, Murad S, Iqbal B. Biphasic & triphasic computed tomography (CT) scan in focal tumoral liver lesions. RadMed Imaging. 2018;3:1012

Gatti M, Calandri M, Bergamasco L, Darvizeh F, Grazioli L, Inchingolo R, Ippolito D, Rousset S, Veltri A, Fonio P, Faletti R. Characterization of the arterial enhancement pattern of focal liver lesions by multiple arterial phase magnetic resonance imaging: comparison between hepatocellular carcinoma and focal nodular hyperplasia. La radiologia medica. 2020 Apr;125(4):348-55

DESSOUKY BA, ABDELAAL E, EBRAHIM T. Triphasic helical CT screening for hepatocellular carcinoma in patients with cirrhosis: opportunities and pitfalls.

Tsurusaki M, Sofue K, Isoda H, Okada M, Kitajima K, Murakami T. Comparison of gadoxetic acid-enhanced magnetic resonance imaging and contrast-enhanced computed tomography with histopathological examinations for the identification of hepatocellular carcinoma: a multicenter phase III study. Journal of gastroenterology. 2016 Jan;51(1):71-9

Afrin R, Sarker S, Mostofa AG, Hossain MS, Nahid S, Saiham S, Alom MZ. The Evaluation of Hepatocellular Carcinoma with Biphasic Contrast Enhanced Spiral CT Scan. Sir Salimullah Medical College Journal. 2022 Apr 27;30(1):61-6

Akuta N, Kawamura Y, Arase Y, Saitoh S, Fujiyama S, Sezaki H, Hosaka T, Kobayashi M, Kobayashi M, Suzuki Y, Suzuki F. Hepatocellular carcinoma is the most common liver-related complication in patients with histopathologically-confirmed NAFLD in Japan. BMC gastroenterology. 2018 Dec;18(1):1-0

Downloads

Published

2022-10-02

How to Cite

Naila Tamkeen, Wahid, G., Adnan Ahmad, Samad, M. ., Rehman, M. ., Khushbakht, & Afsar, M. . (2022). Role of Tri-Phasic Computed Tomography in Evaluation of Hepatocellular Carcinoma Patients with Liver Cirrhosis. Journal of Gandhara Medical and Dental Science, 9(4), 85–89. https://doi.org/10.37762/jgmds.9-4.330

Most read articles by the same author(s)