Salivary Composition of Oral Squamous Cell Carcinoma Patients
DOI:
https://doi.org/10.37762/jgmds.9-3.307Keywords:
Oral Squamous Cell Carcinoma, Sodium, Saliva, Potassium, Proteins, ElectrolytesAbstract
OBJECTIVES:
The purpose of the study was to determine the salivary composition of Oral squamous cell carcinoma patients.
METHODOLOGY:
A retrospective study was conducted over 6 months on data of 60 Oral squamous cell carcinoma patients obtained from the patient records of the Institute of Radiotherapy and Nuclear Medicine, Peshawar. Salivary pH, Sodium, Potassium, and total proteins of Oral squamous cell carcinoma patients were recorded.
RESULTS:
Sodium, Potassium, and total protein concentration in saliva of oral squamous cell carcinoma patients were 23.5 mM/L, 96.7mM/L, and 234.6 mM/L, respectively. These values were significantly higher than normal salivary concentration.
CONCLUSION:
It was concluded that the saliva of oral squamous cell carcinoma patients contains higher concentrations of Sodium, Potassium, and total proteins.
Downloads
Metrics
References
Srinivasan D, Phue WH, Xu K, George S. The type of dietary nanoparticles influences salivary protein corona composition. NanoImpact [Internet]. 2020;19(100238):100238 DOI: https://doi.org/10.1016/j.impact.2020.100238
Mulasi U, Vock DM, Jager-Wittenaar H, Teigen L, Kuchnia AJ, Jha G, et al. Nutrition status and health-related quality of life among outpatients with advanced head and neck cancer. Nutr Clin Pract [Internet]. 2020;35(6):1129–37 DOI: https://doi.org/10.1002/ncp.10476
Khurshid Z, Zafar MS, Khan RS, Najeeb S, Slowey PD, Rehman IU. Role of salivary biomarkers in oral cancer detection. Adv Clin Chem [Internet]. 2018;86:23–70 DOI: https://doi.org/10.1016/bs.acc.2018.05.002
Panarese I, Aquino G, Ronchi A, Longo F, Montella M, Cozzolino I, et al. Oral and Oropharyngeal squamous cell carcinoma: prognostic and predictive parameters in the etiopathogenetic route. Expert Rev Anticancer Ther [Internet]. 2019;19(2):105–19 DOI: https://doi.org/10.1080/14737140.2019.1561288
Mercadante V, Jensen SB, Smith DK, Bohlke K, Bauman J, Brennan MT, et al. Salivary gland hypofunction and/or xerostomia induced by nonsurgical cancer therapies: ISOO/MASCC/ASCO guideline. J Clin Oncol [Internet]. 2021;39(25):2825–43 DOI: https://doi.org/10.1200/JCO.21.01208
Johnson DE, Burtness B, Leemans CR, Lui VWY, Bauman JE, Grandis JR. Head and neck squamous cell carcinoma. Nat Rev Dis Primers [Internet]. 2020;6(1):92 DOI: https://doi.org/10.1038/s41572-020-00224-3
Mæhre H, Dalheim L, Edvinsen G, Elvevoll E, Jensen I-J. Protein determination—method matters. Foods [Internet]. 2018;7(1):5 DOI: https://doi.org/10.3390/foods7010005
Yang G, Rao M, Ren J, Yang X, Wang J, Wu Y, et al. Determination of cervical lymph nodes metastasis and extra nodal extension status by quantitative assessment of border irregularity and apparent diffusion coefficient in patients with tongue squamous cell carcinoma. J Comput Assist Tomogr [Internet]. 2021;45(3):477–84 DOI: https://doi.org/10.1097/RCT.0000000000001170
Khan ZM, Waheed H, Khurshid Z, Zafar MS, Moin SF, Alam MK. Differentially expressed salivary proteins in dental caries patients. Biomed Res Int [Internet]. 2021;2021:5517521 DOI: https://doi.org/10.1155/2021/5517521
Acharya S, Kale J, Hallikeri K, Anehosur V, Arnold D. Clinical significance of preoperative serum C-reactive protein in oral squamous cell carcinoma. Int J Oral Maxillofac Surg [Internet]. 2018;47(1):16–23 DOI: https://doi.org/10.1016/j.ijom.2017.06.017
John AA, Naresh KC, Ranganath V, Subramaniam MR, Patil AS, Jumani PN. Relationship between the nutritional status and antimicrobial protein levels with the periodontal condition in untreated head and neck cancer patients. J Family Med Prim Care [Internet]. 2019;8(10):3325–33 DOI: https://doi.org/10.4103/jfmpc.jfmpc_658_19
Arantes LM, Carvalho D, Melendez AC. Lopes Carvalho A. Serum, plasma and saliva biomarkers for head and neck cancer. Exp rev mol diag. 2018;18(1):85–112. DOI: https://doi.org/10.1080/14737159.2017.1404906
Melo BA de C, Vilar LG, Oliveira NR de, Lima PO de, Pinheiro M de B, Domingueti CP, et al. Human papillomavirus infection and oral squamous cell carcinoma - a systematic review. Braz J Otorhinolaryngol [Internet]. 2021;87(3):346–52 DOI: https://doi.org/10.1016/j.bjorl.2020.10.017
Sun W, Gao M, Hu G, Yuan X. Inflammatory marker predicts outcome of oral squamous cell carcinoma receiving chemo-radiotherapy. Cancer Manag Res [Internet]. 2020;12:12329–35 DOI: https://doi.org/10.2147/CMAR.S277927
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Arbab Zia Ur Rehman, Mohammad Irshad, Sheraz Alam, Ismail Alam Khan, Kanwal Nazir Arbab , Aleena Amin
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.